Monocyte and T cell immune phenotypic profiles associated with age advancement differ between people with HIV, lifestyle-comparable controls and blood donors.


De Francesco D, Sabin CA, Reiss P, Kootstra NA.

Lay summary

People with HIV who are successfully treated show some signs of premature aging and may be more likely to experience clinical conditions.   It has been suggested that HIV may contribute to this through the immune dysfunction and inflammation that it causes.  In a previous study we used a set of markers in the blood to generate an aging score for each person.  In this study, we studied associations between these scores and several immunological markers among participants in the COBRA cohort.  We found that ‘age advancement’ (a score that would predict an older age than someone’s true age) wa

Research theme