Publications

Plasma nucleotide reverse transcriptase inhibitor concentration and their associations with liver and renal parameters in people living with HIV. eir associations with liver and renal parameters in people living with HIV.

Authors

Wang X, Boffito M, Dickinson L, Bagkeris E, Khoo S, Post FA, Vera J, Williams I, Ndoutoumou A, Anderson J, Mallon P, McClure M, Winston A, Sabin C; POPPY Study.

Lay summary

We know very little about whether the amount of antiretroviral drug that a person gets is related to their risk of liver and kidney problems.  Through the POPPY study, we analysed associations between blood measures of liver and kidney function, and the amounts of some drugs (TDF, FTC, ABC and 3TC) that can be measured in a person’s blood.  While we found no associations between the amount of drug found in the blood and measures of liver disease, people with poorer kidney function tended to have higher levels of TDF, FTC and 3TC in their blood. 

Research theme