NRTI exposure, age and toxicity

The pharmacokinetics of drugs change with age. Whilst tenofovir has been shown to cause toxicity more frequently in older PLWH, data on other NRTI drugs and the potential for them to cause renal toxicity in older PLWH is lacking.  Furthermore, the clinical consequences of available findings relating to tenofovir are unclear and there are no recommendations on individual dose adjustment in the ageing population. This project will perform a bioanalysis of plasma NRTIs in PLWH aged > 50 years in order to investigate whether there is a clear correlation between age, drug exposure and toxicity.